Most read papers

Which papers are being downloaded the most?
The number of downloads in the 12 months to the end of November 2011 are shown below

1880	Different proteolipid protein mutants exhibit unique metabolic defects Maik Hüttemann, Zhan Zhang, Chadwick Mullins, Denise Bessert, Icksoo Lee, Klaus-Armin Nave, Sunita Appikatla and Robert Skoff (2009) 1, e0014 doi:10.1042/AN20090028 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
1793	Review Animal models for Alzheimer’s disease and frontotemporal dementia: a perspective Jürgen Götz and Naeman Götz (2009) 1, e0019 doi:10.1042/AN20090042 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
1251	Review Molecules and mechanisms involved in the generation and migration of cortical interneurons Francesca Chiara, Luis Hernandez-Miranda and John Parnavelas (2010) 2, e0031 doi:10.1042/AN20090053 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
1214	Review Mitochondria and Neuroplasticity Mark Mattson, Aiwu Cheng and Yan Hou (2010) 2, e0045 doi:10.1042/AN20100019 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
1024	Prolonged exposure of cortical neurons to oligomeric amyloid-beta impairs NMDA receptor function via NADPH oxidase-mediated ROS production: protective effect of green tea (-)-epigallocatechin-3-gallate Yan He, Jiankun Cui, James Lee, Shinghua Ding, Malgorzata Chalimoniuk, Agnes Simonyi, Albert Sun, Zezong Gu, Gary Weisman, W. Wood and Grace Sun (2011) 3, e0050 doi:10.1042/AN20100025 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
925	Transcriptional Activation of Endothelial Cells by TGFβ Coincides with Acute Microvascular Plasticity Following Focal Spinal Cord Ischemia-Reperfusion Injury Richard Benton, Melissa Maddie, Toros Dincman, Theo Hagg and Scott Whittemore (2009) 1, e0015 doi:10.1042/AN20090008 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
879	Review The role of microglia in synaptic stripping and synaptic degeneration: a revised perspective V Hugh Perry and Vincent O'Connor (2010) 2, e0047 doi:10.1042/AN20100024 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
841	Review Leucine Rich Repeat Kinase 2 mutations and Parkinson’s disease: Three Questions Elisa Greggio and Mark Cookson (2009) 1, e0002 doi:10.1042/AN20090007 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
839	Inflammatory cytokines IL-1β and TNFα regulate p75NTR expression in CNS neurons and astrocytes by distinct cell type specific signaling mechanisms Soyoung Choi and Wilma Friedman (2009) 1, e0010 doi:10.1042/AN20090009 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
814	Targeted overexpression of a golli–myelin basic protein isoform to oligodendrocytes results in aberrant oligodendrocyte maturation and myelination Erin Jacobs, Kathy Kampf, Wendy Macklin, Samuel Reyes, Celia Campagnoni, Irene Givogri, Vance Handley, Vilma Spreuer, Robin Fisher and Anthony Campagnoni (2009) 1, e0017 doi:10.1042/AN20090029 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
752	Dual vulnerability of Tau to Calpains and Caspase-3 proteolysis under neurotoxic and neurodegenerative conditions Ming Cheng Liu, Firas Kobeissy, Wenrong Zheng, Zhiqun Zhang, Ronald Hayes and Kevin Wang (2011) 3, e0051 doi:10.1042/AN20100012 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
740	Expression of the circadian clock gene Period2 in the hippocampus: Possible implications for synaptic plasticity and learned behavior Louisa Wang, Joanna Dragich, Takashi Kudo, Irene Odom, David Welsh, Thomas O'Dell and Christopher Colwell (2009) 1, e0012 doi:10.1042/AN20090020 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
699	T cell production of matrix metalloproteases and inhibition of parasite clearance by TIMP-1 during chronic Toxoplasma infection in the brain Robin Clark, J. Nance, Shahani Noor and Emma Wilson (2011) 3, e0049 doi:10.1042/AN20100027 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
698	Inhibiting heat shock protein 90 reverses sensory hypoalgesia in diabetic mice Michael Urban, Chengyuan Li, Cuijuan Yu, Yuanming Lu, Joanna Krise, Michelle McIntosh, Roger Rajewski, Brian Blagg and Rick Dobrowsky (2010) 2, e0040 doi:10.1042/AN20100015 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
680	Apotransferrin-induced recovery after hypoxic-ischemic injury on myelination Mariano Guardia Clausi, Laura Pasquini, Eduardo Soto and Juana Pasquini (2010) 2, e0048 doi:10.1042/AN20100020 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
680	Brain injury expands the numbers of neural stem cells and progenitors in the SVZ by enhancing their responsiveness to EGF Dhivyaa Alagappan, Deborah Lazzarino, Ryan Felling, Murugabaskar Balan, Sergei Kotenko and Steven Levison (2009) 1, e0009 doi:10.1042/AN20090002 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
657	MyD88 expression by CNS-resident cells is pivotal for eliciting protective immunity in brain abscesses Sarita Garg, Jessica Nichols, Nilufer Esen, Shuliang Liu, Nirmal Phulwani, Mohsin Syed, William Wood, Yongqing Zhang, Kevin Becker, Amy Aldrich and Tammy Kielian (2009) 1, e0007 doi:10.1042/AN20090004 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
655	Review Genetic mouse models of Huntington’s disease: focus on electrophysiological mechanisms Carlos Cepeda, Damian Cummings, Véronique André, Sandra Holley and Michael Levine (2010) 2, e0033 doi:10.1042/AN20090058 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
638	Wnt5a controls neurite development in olfactory bulb interneurons Darya Pino, Youngshik Choe and Samuel Pleasure (2011) 3, e0059 doi:10.1042/AN20100038 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
625	*Increased Plp1* gene expression leads to massive microglial cell activation and inflammation throughout the brain** Carrie Tatar, Sunita Appikatla, Denise Bessert, Ajaib Paintlia, Inderjit Singh and Robert Skoff (2010) 2, e0043 doi:10.1042/AN20100016 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
607	The anti-inflammatory effects of dimethyl fumarate in astrocytes involve glutathione and heme-oxygenase 1 Shao Lin, Lucia Lisi, Cinzia Dello Russo, Paul Polak, Anthony Sharp, Guy Weinberg, Sergey Kalinin and Douglas Feinstein (2011) 3, e0055 doi:10.1042/AN20100033 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
593	Altered hippocampal morphology in unmedicated patients with major depressive illness Carrie Bearden, Paul Thompson, Christina Avedissian, Andrea Klunder, Mark Nicoletti, Nicole Dierschke, Paolo Brambilla and Jair Soares (2009) 1, e0020 doi:10.1042/AN20090026 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
585	Glial glucokinase expression in adult and post-natal development of the hypothalamic region Carola Millán, Fernando Martínez, Christian Cortés-Campos, Isabel Lizama, Maria Yañez, Paula Llanos, Karin Reinicke, Federico Rodríguez, Bruno Peruzzo, Francisco Nualart and Maria García (2010) 2, e0035 doi:10.1042/AN20090059 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
584	Calorie restriction as an anti-invasive therapy for malignant brain cancer in the VM mouse Laura Shelton, Leanne Huysentruyt, Purna Mukherjee and Thomas Seyfried (2010) 2, e0038 doi:10.1042/AN20100002 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
582	Dynamic imaging of cannabinoid receptor 1 vesicular trafficking in cultured astrocytes Kyle Osborne, William Lee, Erik Malarkey, Andrew Irving and Vladimir Parpura (2009) 1, e0022 doi:10.1042/AN20090040 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
580	Review The curious case of NG2 cells: transient trend or game changer? Jean-Marie Mangin and Vittorio Gallo (2011) 3, e0052 doi:10.1042/AN20110001 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
567	Dual Induction of TREM2 and Tolerance related transcript, Tmem176b in amyloid transgenic mice: implications for vaccine-based therapies for Alzheimer’s disease Benoit Melchior, Angie Garcia, Bor-Kai Hsiung, Katherine Lo, Jonathan Doose, J. Thrash, Anna Stalder, Matthias Staufenbiel, Harald Neumann and Monica Carson (2010) 2, e0037 doi:10.1042/AN20100010 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
564	Cuprizone demyelination of the corpus callosum in mice correlates with altered social Interaction and impaired bilateral sensorimotor coordination Norah Hibbits, Ravinder Pannu, T. Wu and Regina Armstrong (2009) 1, e0013 doi:10.1042/AN20090032 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
557	The neurogenic basic helix-loop-helix transcription factor NeuroD6 concomitantly increases mitochondrial mass and regulates cytoskeletal organization in the early stages of neuronal differentiation Kristin Baxter, Martine Uittenbogaard, Jeongae Yoon and Anne Chiaramello (2009) 1, e0016 doi:10.1042/AN20090036 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
552	Memory deficits in APP23/Abca1+/- mice correlate to the level of Aβ oligomers Iliya Lefterov, Nicholas Fitz, Andrea Cronican, Preslav Lefterov, Matthias Staufenbiel and Radosveta Koldamova (2009) 1, e0006 doi:10.1042/AN20090015 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
534	The neurogenic basic helix-loop-helix transcription factor NeuroD6 confers tolerance to oxidative stress by triggering an anti-oxidant response and sustaining the mitochondrial biomass Martine Uittenbogaard, Kristin Baxter and Anne Chiaramello (2010) 2, e0034 doi:10.1042/AN20100005 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
523	Outer Mitochondrial Membrane Localization of Apoptosis-Inducing Factor: Mechanistic Implications for Release Seong-Woon Yu, Yingfei Wang, Didrik Frydenlund, Ole Petter Ottersen, Valina Dawson and Ted Dawson (2009) 1, e0021 doi:10.1042/AN20090046 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
522	Amyloid-β directly induces spontaneous calcium transients, delayed intercellular calcium waves, and gliosis in rat cortical astrocytes Siu-Kei Chow, Diana Yu, Christopher MacDonald, Marius Buibas and Gabriel Silva (2010) 2, e0026 doi:10.1042/AN20090035 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
520	Review The multiple roles of myelin protein genes during the development of the oligodendrocyte Daniel Fulton, Pablo Paez and Anthony Campagnoni (2010) 2, e0027 doi:10.1042/AN20090051 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
512	Hyperglycemia and diabetes impair gap junctional communication among astrocytes Gautam Gandhi, Kelly Ball, Nancy Cruz and Gerald Dienel (2010) 2, e0030 doi:10.1042/AN20090048 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
504	Olfactory discrimination training up-regulates and reorganizes expression of microRNAs in adult mouse hippocampus Neil Smalheiser, Giovanni Lugli, Angela Lenon, John Davis, Vetle Torvik and John Larson (2010) 2, e0028 doi:10.1042/AN20090055 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
481	In vitro growth environment produces lipidomic and electron transport chain abnormalities in mitochondria from non-tumorigenic astrocytes and brain tumors Michael Kiebish, Xianlin Han, Hua Cheng and Thomas Seyfried (2009) 1, e0011 doi:10.1042/AN20090011 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
470	Glypican-1, phosphacan/receptor protein-tyrosine phosphatase-ζ/β and its ligand tenascin-C are expressed by neural stem cells and neural cells derived from embryonic stem cells Mary Abaskharoun, Marie Bellemare, Elizabeth Lau and Richard Margolis (2010) 2, e0039 doi:10.1042/AN20100001 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
467	Commentary When the tail can't wag the dog: the implications of CNS-intrinsic initiation of neuroinflammation Deirdre Davis and Monica Carson (2009) 1, e0008 doi:10.1042/AN20090024 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
461	Lack of X-linked inhibitor of apoptosis protein leads to increased apoptosis and tissue loss following neonatal hypoxic-ischemic brain injury Tim West, Madeliene Stump, Gregory Lodygensky, Jeff Neil, Mohanish Deshmukh and David Holtzman (2009) 1, e0004 doi:10.1042/AN20090005 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
449	Regulated release of BDNF by cortical oligodendrocytes is mediated through metabotropic glutamate receptors and the PLC pathway Issa Bagayogo and Cheryl Dreyfus (2009) 1, e0001 doi:10.1042/AN20090006 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
448	Astrocytic gap junctional communication is reduced in amyloid-β-treated cultured astrocytes but not in Alzheimer’s disease transgenic mice Nancy Cruz, Kelly Ball and Gerald Dienel (2010) 2, e0041 doi:10.1042/AN20100017 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
443	Regulation of oligodendrocyte progenitor cell maturation by PPARdelta: effects on bone morphogenetic proteins Maria Simonini, Paul Polak, Anne Boullerne, Jeffery Peters, Jill Richardson and Douglas Feinstein (2010) 2, e0025 doi:10.1042/AN20090033 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
428	Ganglioside metabolism in a transgenic mouse model of Alzheimer’s disease: Expression of Chol-1α antigens in the brain Robert Yu, Toshio Ariga, Makoto Yanagisawa, Chandramohan Wakade, Jerry Buccafusco, Michael MCDonald and Susumu Ando (2010) 2, e0044 doi:10.1042/AN20100021 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
423	Point mutation in the mouse P2X7 receptor affects intercellular calcium waves in astrocytes Sylvia Suadicani, Rodolfo Iglesias, David Spray and Eliana Scemes (2009) 1, e0005 doi:10.1042/AN20090001 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
406	Regulation of store-operated and voltage-operated Ca⁺⁺ channels in the proliferation and death of oligodendrocyte precursor cells by Golli proteins P Paez, D Fulton, V Spreuer, V Handley, C Campagnoni and A Campagnoni (2009) 1, e0003 doi:10.1042/AN20090003 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
403	Cytotoxic effects of GM1 ganglioside and amyloid β-peptide on mouse embryonic neural stem cells Makoto Yanagisawa, Toshio Ariga and Robert Yu (2010) 2, e0029 doi:10.1042/AN20090063 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
401	A single nucleotide polymorphism in the Bax gene promoter affects transcription and influences retinal ganglion cell death Sheila Semaan, Yan Li and Robert Nickells (2010) 2, e0032 doi:10.1042/AN20100003 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
383	Commentary Filming the glial dreams: real-time imaging of cannabinoid receptors trafficking in astrocytes Alexei Verkhratsky (2009) 1, e0023 doi:10.1042/AN20090049 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
361	Canonical Wnt signaling requires the BMP pathway to inhibit oligodendrocyte maturation Keith Feigenson, Mary Reid, Jill See, E. Crenshaw and Judith Grinspan (2011) 3, e0061 doi:10.1042/AN20110004 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF